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1.6 Biochemical and metabolic profiling The pathogenesis of neurodegenerative disorders generally involves a complex physiopathology that includes age-related changes, abnormal function and accumulation of brain proteins, inflammation, disruption of energy homeostasis, hormonal imbalances, metabolic imbalances, DNA damage, among other processes (Gadhave et al., 2024)

Once initiated, clinicians should consider daily whether NMB remains helpful and consider discontinuation at the earliest opportunity

In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties

glutathione outside cells may not contribute in the same way

68 In the cerebellum, 8-oxo-dG was negatively associated with GSH/GSSG in the combined case and control cohort (Figure 3)

GSH (Glycine), (Glutamine), (Cystein) (Tripeptide)