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For the C5 domain of NocB a unique amino acid located immediately upstream to the conserved HHxxxDG motif has been reported, which is crucial for the proper function of C5 29

The entire submission takes roughly 10 to 15 minutes

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Abbreviations GLP-1: Glucagon-like peptide 1 GIP: Glucose-dependent insulinotropic polypeptide GLP-1R: Glucagon-like peptide 1 receptor GIPR: Glucose-dependent insulinotropic polypeptide receptor ASCVD: Atherosclerotic cardiovascular disease HF: Heart failure HFpEF: Heart failure with preserved ejection fraction HFrEF: Heart failure with reduced ejection fraction T2DM: Type 2 diabetes mellitus EF: Ejection fraction LVEF: Left ventricular ejection fraction LVEDV: Left ventricular end-diastolic volume LVESV: Left ventricular end-systolic volume LVSV: Left ventricular stroke volume CO: Cardiac output CI: Cardiac index BSA: Body surface area LVIDs: Left ventricular internal diameter in systole LVIDd: Left ventricular internal diameter in diastole LVFS: Left ventricular fractional shortening LVAWTs: The thickness of the left ventricular anterior wall in systole LVAWTd: The thickness of the left ventricular anterior wall in diastole LVPWTs: The thickness of the left ventricular posterior wall in systole LVPWTd: The thickness of the left ventricular posterior wall in diastole LV: Left ventricular mass RWT: Relative wall thickness LVRi: Left ventricular remodelling index AngII: Angiotensin II Veh: Vehiculum Lira: Liraglutide TZP: Tirzepatide ECG: Electrocardiography References Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emerson SS, Kahn SE, et al

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doi:10.1111/jdi.13764