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No head-to-head RCT data exist, but we recently published a case report describing differences in efficacy of liraglutide compared with semaglutide (once-weekly subcutaneous administration) in an individual with primary BAD (16)

While semaglutide GLP-1 is highly effective, it is important to address potential gastrointestinal side effects, such as nausea and diarrhea, which are generally transient and manageable

Mild nausea and vomiting were reported as mild in 7.3% in NA-931-treated subjects

For Glucagon z-scores there were a significant difference in associations between boys and girls for the surrogate marker for insulin resistance HOMA-IR ( p = 0.037) and also a borderline significant difference in associations between sexes for HOMA2-IR ( p = 0.067)

Understanding why nausea occurs is the first step in managing it effectively