semaglutide effect on period and metformin improve menstrual cyclicity in overweight/obese women with polycystic ovary syndrome: a randomized trial Woman With PCOS Takes Semaglutide:

I do feel the hardware is causing significant discomfort still and may not ever go away unless it is removed

The inhibitory effect of glucocorticoids on GH release is possibly mediated by increase in expression of somatostatin (368)

Cobb, J

gallbladder removal, knee replacement)

Since switching to Biotics Research, Ive seen a significant improvement in both

Results announced in December 2025 confirmed the Phase 2 findings at a longer timepoint (Lilly Press Release, Dec 2025): The 28.7% weight loss at 68 weeks exceeds both semaglutide (~15% in STEP trials) and tirzepatide (~22.5% in SURMOUNT trials) at similar timepoints