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Furthermore, hyperglycemia and hyperinsulinemia reportedly increase UDP-GlcNAc levels in skeletal muscle [64,65], and O-GlcNAc levels have been reported to be elevated in the corneas, pancreases, and skeletal muscles of diabetic or insulin resistant rats [66,67]

DOX has been linked to the production and accumulation of ROS in the mitochondria, which can damage mitochondrial DNA and impair the activity of the mitochondria 87

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It also explains why so much of the published work points at the gut

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