doi: 10.1172/JCI93820 196 MohammadianT.Ghanei-MotlaghR.MolayemraftarT.MesbahM.ZareaM.MohtashamipourH.et al
It has been FDA-approved for weight loss since 1959, making it one of the longest-standing obesity medications available
In addition, surface transporters of epithelial cells, such as glucose transporter GLUT2 and amino acid transporter SGLT1, can specifically transport nutrients, further enhancing the selectivity of permeability
They included 12 SGLT2i trials with 73,238 participants, of whom 3,065 were on a GLP-1 RA: they found that the benefits of SGLT2i on MACE were consistent regardless of background GLP-1 RA use (HR = 0.81 in patients receiving GLP-1 RA vs HR = 0.90 in those not receiving GLP-1RA) with no significant heterogeneity (p = 0.31)
Next, in vitro experiments in primary hepatocytes from DIO mice were performed to unravel possible cell autonomous effects of G49
The interpretation of these results should always take into account that reference ranges vary by laboratory, age, marker and clinical context
