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For someone starting at 200 lbs, the number approaches 48 lbs

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Subsequent assay studies indicated that (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl) butan-1-one (40) possesses strong in vitro activity, favorable selectivity, and in vivo efficacy in mouse models (Figure 6)

At very high doses, a fishy body odor has been reported in rare cases