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Although potentiation of SP activity has been postulated to underlie the pathophysiology of nasopharyngitis or neurogenic inflammation occasionally reported with use of DPP4 inhibitors, SP is also rapidly cleaved by angiotensin-converting enzyme and neutral endopeptidase, and levels of intact vs cleaved SP are very low and difficult to quantify in vivo

A Phase I safety study and a Phase II ulcerative colitis trial of the BPC-157 formulation PL 14736 were conducted by the Croatian pharmaceutical company Pliva, but full peer-reviewed Phase II efficacy results have not been published

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In the adjuvant arthritis studies, the lesions' development was considerably reduced after a single NaBPC157 application and even more attenuated in rats treated daily with NaBPC157

Around 50% of people lose at least 5% of their starting weight within 6 months

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