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doi: 10.1016/S0891-5849(01)00618-9

10.1074/jbc.273.4.2015

Restoring glutathione, replenishing magnesium, clearing histamine, and reducing cumulative exposure can meaningfully reverse sensitivity over four to twelve weeks in my experience

This is important because when you have high blood sugar levels, your body assumes you have plenty of energy and that fat doesnt need to be burned

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Thus, it is possible that longer-term interventions are needed to elicit a change in basal serum IGF-1 concentrations in humans