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En las ratas obesas prediabticas OLETF (Otsuka-Long-Evans-Tokushima Fatty rats) se observ que despus de 12 semanas de tratamiento con la liraglutida exista una adecuada conservacin de la morfologa de los islotes pancreticos, regulacin a la alta de la expresin de factor antiapopttico Bcl-2 y regulacin a la baja de la expresin del factor proapopttico Bax, resultados que sugieren que la liraglutida tiene un papel protector en la formacin y la funcin del islote pancretico mediante el control de las vas apoptticas, lo que permite mantener la funcin endocrina de la clula beta y prevenir las alteraciones de la glucosa y la aparicin de DM244

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