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Before we switch the focus on risk reduction for CV evens in obese patients only to #GLP-1 agonists, lets not forget aggressive reductions in #LDL #ApoB #NONHDL along with some reductions in #Lpa with #PCSK9i See our editorial with Layla Abushamat The Texas Heart Institute at Baylor College of Medicine Cardiometabolic Health Congress National Lipid Association Greatest benefit seen in patients who are #obese with elevated #hsCRP Looking beyond changes in hsCRP to potential anti-inflammatory effects of #PCSK9i and marked reduction in LDL-C, Non-HDL-C, apoB and Lp(a) Greater benefit for PCSK9i #evolocumab observed for those with higher BMI

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Glutaryl-L-carnitine-d6 deuterated acylcarnitine can be used to quantify its physiological counterpart in a variety of biological samples using mass spectrometry to study metabolic profiles and monitor the function of associated enzymes