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2000 in Hormone Research showed that 21-day oral AOD-9604 (500 mcg/kg/day) reduced body weight gain by roughly 50% in obese Zucker rats with no insulin sensitivity penalty
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GSH also catalytically detoxifies cells from peroxides such as hydroperoxides (H 2 O 2 ), peroxynitrite (OONO ), and lipid peroxides (LOO ) by the action of GSH peroxidases (GPX) and peroxiredoxins (PXR)
However, variant interpretation is complicated by factors such as membrane targeting: for instance, a serine mutation at one of the other Na + -binding residues, N210, causes a reduction in uptake, but also shows mixed localisation, 11 which may itself contribute to disease
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