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This successful HSCT demonstrated that reversal of SCD could be achieved without complete reversal of the hematological phenotype to HbAA, and paved the way for bone marrow transplant (BMT) as a curative option for children with severe SCD (Walters et al., 1996b)

In severe acute infections, this systemic consumption can completely drain the body's antioxidant reserves

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By interfering with this survival pathway, FOXO4-DRI induces apoptosis specifically in senescent cells while leaving healthy cells unaffected