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other intestinal hormones such as GIP, PYY, Neurotensin, INSL-5 or the GIP co-secreted Xenin (217) might play an important role (Figure 2)

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Patients with type 2 diabetes already have an elevated baseline risk of pancreatic cancer compared to the general population

Thus, regulating mitochondrial function may suppress neuroinflammation by modulating microglial activation and glutamatergic dysregulation

1 , 2 Constipation is reported in 4% to 12% of patients and occurs more frequently in individuals with obesity, likely due to the use of higher doses