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In eye diseases like DR, high blood glucose and oxidative stress activate the Notch1-Hes signaling pathway, leading to ECM imbalance and promoting vascular dysfunction, inflammation, and retinal damage (Fan et al., 2020)

Once reconstituted, always refrigerate and use within 46 weeks

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[9] [12] This partly explains why pharmacological GLP-1 receptor agonists can still be effective in this population