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NAD+ levels drop 50% by middle age , impairing energy production and DNA repair mechanisms that are crucial for healthy aging and cellular function

Evidence strength: Strong for Thymosin Beta-4 based on Phase 3 trial

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Whether this translates into measurable longevity benefit in humans is a question that awaits the randomized trials that the field urgently needs

JCI Insight 5 , e133501 (2020)

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