The activation of HO-1, a mitochondrial enzyme that catalyses the degradation of haem to generate ferrous iron, results in increased mitochondrial iron, thereby upregulating ferroptosis [139, 140]
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The BRD4 binding motif, VHL E3 ligase binding motif, linker, and structural modifications for enhanced CD36 binding affinity and permeability are colored as red, blue, black, and orange, respectively
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A therapeutic approach combining coenzyme Q 10 with other antioxidants might prove to be more effective to target co-existing metabolic disorders in individuals at risk for cardiovascular disease (55)