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[DOI] [PubMed] [Google Scholar] 82.Fouzder C., Mukhuty A., Mukherjee S., Malick C., Kundu R
17,18 The most common offending drugs include antiepileptics (carbamazepine, phenytoin, lamotrigine, phenobarbital), allopurinol, sulfonamides (sulfasalazine, dapsone, trimethoprim-sulfamethoxazole), minocycline, vancomycin, and antituberculosis agents (isoniazid, rifampicin, ethambutol, pyrazinamide)
These reagents support two clinically relevant concepts: (1) Combination sensitization: FSP1 blockade can sensitize tumors to upstream ferroptosis-inducing nodes (for example, GPX4 inhibition or cystine import disruption), consistent with the idea that tumors rely on redundant antioxidant systems
Effects peak within days of dose increases and improve over 2 to 3 weeks
What is the role of ferroptosis in glioma immunotherapy tolerance
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