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A comprehensive immunogenicity assessment should combine computational epitope prediction, MHC-associated peptide proteomics (MAPPs), T-cell and cytokine-release assays, multi-tiered ADA testing, and advanced mass spectrometry characterization

Compounded medications are not FDA-approved, and compounded semaglutide is not established as equivalent to the branded products

Furthermore, GLP-1RA is related to decreased body weight, which is unfavorable for bone fractures as weight loss induces mechanical loading and bone mass decrease

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doi: 10.1007/s00228-023-03025-0