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Sulfite oxidase is encoded by the SUOX gene

The increase in ROS production caused by hyperglycemia occurs through the following ways: activation of the protein kinase C (PKC) pathway via diacylglycerol (DAG), increased hexosamine pathway flux, increased production of advanced glycation-end product, and increased flux in the polyol pathway (32, 33)

Key Takeaway: Supplementing with glutathione is most effective when supported by cofactors like B vitamins and selenium, and when delivered in a liposomal format for maximum absorption

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doi:10.1177/1535370217736512 2025 The Author(s)