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Research conducted by (Shoba et al., 1998) revealed that the amalgamation of curcumin and piperine enhanced curcumins bioavailability in humans by 2000%

Subsequently, OPN induces tumor cells to produce TGF- , which in turn upregulates PD-1 expression on immune cells and ultimately increases the sensitivity of breast cancer to PD-1 immunotherapy

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Salisbury VA Medical Center, Salisbury, NC, 28144, USA

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However, the exact molecular mechanisms responsible for this preserved effect remains unclear