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Neuro-Endocrinol Lett 34:18599, PMID: 23685416 Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ (2012) Increased ventricular lactate in chronic fatigue syndrome

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The article reports gastrointestinal adverse events in 25 to 40 percent of participants in clinical trials, with severity often declining after four to eight weeks of continued use

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DSIP was discovered decades ago and initially attracted substantial scientific interest, yet large contemporary clinical programs did not emerge