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and GCGR activation increases hepatic glucose output (balanced by incretin-mediated insulin), promotes energy expenditure through thermogenesis, and enhances hepatic fat oxidation

GIP activation may additionally potentiate the insulin secretion effects of GLP-1 activation on the pancreas and the weight loss effects of GLP-1 activation on CNS [13]

Sobos approach is especially relevant

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Side effects by dose level Note: These are approximate rates from clinical trials

If carried out as planned, these changes could make GLP-1s (and potentially other important drugs) more affordable for millions of Americans