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Mol Nutr Food Res 2020;64:e1900978
As body composition changesparticularly with loss of adipose tissuethermoregulation is affected because fat serves primarily as insulation, while heat generation comes largely from metabolically active lean tissue
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As well as chemical targeting, enzymatic targeting is another challenging strategy and cyst(e)inase-mediated depletion of serum cysteine and cystine pools has already been demonstrated to suppress the growth of tumours in different animal models
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