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Research design and methods: We conducted a retrospective cohort study of 5,384 adults with T2D, enrolled in Leumit Health Services, who initiated semaglutide therapy between February 1, 2019, and December 31, 2022

With the treatment target changing from lowering to normalizing ALP many patients with mildly high serum ALP levels (considered nowadays as non-responders) were excluded from these studies

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