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While there has been no change in law, CMS clarified that anti-obesity medications (AOMs) that receive FDA approval for an additional medically accepted indication can be considered a Part D drug for that specific use

Kisspeptin is strictly a research compound used only in clinical settings

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The Biology of Regain After significant weight loss through any method, the body mounts a coordinated biological response aimed at returning to its previous weight

doi: 10.1038/nrendo.2015.231

Individual results will vary based on factors including age, baseline weight, metabolic health, consistency of use, lifestyle factors, genetic factors, current medications, and other individual variables