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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

582 These findings suggest that lactate not only affects T-cell differentiation but also may modulate T-cell effector functions, particularly in tissue microenvironments

Matter 1 (2), 345368

SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism

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Mol Immunol 132:227235 Zhang Z, Chen W-Q, Zhang S-Q, Bai J-X, Lau C-L, Sze SC-W, Yung KK-L, Ko JK-S (2022) The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment