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Key takeaways: Methylene blue is a salt and dye with antioxidant, anti-inflammatory, antidepressant and analgesic properties

Alterations in key metabolic pathways such as glycolysis and oxidative phosphorylation profoundly affect the activation, differentiation and function of B and T cells, monocytes, neutrophils and other immune cells, driving inflammation and tissue injury

( Response: We refer readers to the more substantial discussion of these comments and our responses to these comments in section XIX

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