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The combination therapy relieved pain at rates similar to those for high-dose monotherapy as measured by the change in average pain on the Brief Pain Inventory Modified Short Form (mean change: combination, 2.35

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10.1371/journal.pone.0133783 PLoS One 56 ZilleM.KaruppagounderS

maximum 50 mg/day) and four children discontinued the treatment because of an adverse effect ( Clinical studies for treatments that could address redox metabolism include N -acetyl-l-cysteine, methylcobalamin, methylcobalamin combined with oral folinic acid and a multivitamin (as previous mentioned)