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APAP concentration in cerebrospinal fluid followed a similar time profile pattern, reaching slightly higher concentrations (1 and 3 mM, respectively) (130)

The condition may be treated with severe dietary restrictions (stopping oral food and fluids), administering fluids through an IV, and using a nasogastric tube for suction to relieve the pressure

However, emerging research and case reports support the biological plausibility of these changes

Winslet MC, Poxon V, Allan A, Keighley MR

At present, diagnostic tools for neurodegenerative diseases primarily rely on the assessment of late-stage clinical symptoms or costly neuroimaging examinations and lack pathology-based biomarkers that would enable intervention in the early stages of the disease (76)