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Am J Med 2013;126(2):141-9

Old, fragmented collagen gets cleared away

This in turn destabilizes histone-DNA binding and assists transcription

The investigators assessed molecular markers associated with autophagy, apoptosis, insulin-like growth factor signaling, oxidative stress, and histological integrity in skeletal muscle tissue to clarify whether GHRP-6 has protective or modulatory effects under conditions of DOX-induced damage