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5-Amino-1MQ (5-amino-1-methylquinolinium) is the most studied inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme that acts as a metabolic brake in fat cells by depleting both SAM (S-adenosylmethionine) and NAD+ precursors

Vitamin B12 Fact Sheet for Health Professionals

This is one of the most important parts of the conversation

You get it through animal foods, such as eggs, dairy, seafood, poultry, and beef

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Adequate protein (0.8-1g per pound of body weight) preserves lean mass while the deficit targets fat