Fatigue affects approximately 30% of patients in the first 8 weeks of GLP-1 therapy, though most experience improvement by week 12
Lecomte M, Coudelo L, Meugnier E, Plaisanci P, Ltisse M, Benoit B, et al
While universal deprescribing is unlikely to drive optimal results, it may make sense on an individual basis to explore discontinuation, lowering the dose, or increasing time between doses, as patients enter a maintenance phase with their treatment
Hormone Balancing: If low estrogen levels are contributing to hair loss, addressing hormonal imbalances through medical or natural means can be beneficial
Beyond BMI criteria, ideal candidates are patients who have attempted lifestyle modifications (diet, exercise) without achieving adequate or sustained weight loss
Discussion Our study shows that HFD-induced obesity results in many disturbances in the level of low molecular weight thiols and reactive sulfur species in the rat liver