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Meanwhile, the accumulation of ROS, release of mtDNA, and activation of inflammasome establish a potential self-reinforcing cycle of energy deficiency and inflammation, which may contribute to the delayed and persistent nature of PEM symptoms

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Drug Targets 8 , 333345 (2007)

However, they are approximately 40% less effective in comparison to injections

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In in vivo studies, subcutaneous injection frequency, injection site rotation, and peptide stability in the dosing vehicle all represent variables that researchers must account for when designing replicable experimental protocols