Exendin-4 Attenuates Pain-Induced Cognitive Impairment by Alleviating Hippocampal Neuroinflammation in a Rat Model of Spinal Nerve Ligation
See recent WSJ article here Enthusiasts (biohackers?) and some longevity-focused clinicians believe that microdosing these drugs offers benefits beyond weight loss, such as improved metabolic health, glycemic control, reduced systemic inflammation, and potentially even a lower risk of age-related diseases
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become common therapies in the management of chronic conditions such as diabetes and obesity
Turning that mechanistic insight into medicines is the province of applied discovery, traced in how this receptor biology was turned into a drug-discovery platform
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Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity