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Selectivity validation using GSH-depleted controls (e.g., buthionine sulfoximine [BSO]-treated cells) is a standard practice in well-designed preclinical studies
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The medication is one component of the program, not the program itself
However, most prostate cancers eventually become resistant to androgen deprivation and progress to castration-resistant disease
These radicals can accelerate the aging process if they are not allowed to move and are stuck together in a place
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