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Although there is debate as to whether current GLP-1 agonists can readily cross the bloodbrain barrier, there is evidence to suggest that most do and exhibit CNS activity in humans [50]

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A administrao de exendina-4 em modelos animais resultou na reduo da dor, inibio de fatores inflamatrios como IL-1 e TNF-, alm de atenuar a ativao da microglia um processo fundamental na proteo neuronal

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Cancer can take years or decades to develop