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(PubMed) Ledezma E, DeSousa L, Jorquera A, et al

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When mitochondrial glutathione becomes depleted, oxidative damage accelerates at the primary site of ROS generation

The randomized and placebo-controlled design of all included trials and the double-blind design of most of them can also be other strengths and due to the RCT nature of the studies, the drugs used by the patients (especially in diabetic patients), the diet and the level of physical activity of the participants were controlled and in fact their effects were considered and it can be said that the pure effects of L-carnitine was evaluated