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JACC Basic to Translational Science

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We found that the ebselen could significantly promote SGN survival, decrease SGN apoptosis, and reduce intracellular ROS levels after peroxynitrite exposure in vitro , while the deficiency of GPX1 led to opposite patterns of the above effects

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This unusual pathway activates the VEGFR2-Akt-eNOS signaling cascade in vascular endothelial cell cultures[1]

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