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This ensures: Correct dosage Safe administration Personalized treatment plan 2

Primary endpoint met: A significantly higher percentage of patients achieved a 4-point improvement in SLE Responder Index 4 (SRI-4) at one year with Gazyva/Gazyvaro vs

Carnitine administration is not indicated for uremic patients on a regular basis (Schrder et al., 2003), although symptomatic dialysis patients who do not react to normal treatment can benefits from it (Schreiber, 2006)

Standard / Gradual Approach (3 mL = ~6,667 mcg/mL) Reconstitute: Add 3.0 mL bacteriostatic water to one 20 mg blend vial ~6,667 mcg/mL total blend (a 10 mg vial ~3,333 mcg/mL)

Exercise variables add another layer of complexity

170 We speculate that the above differences are related to TMAO dosage and cell type heterogeneity, but there is currently no direct evidence to prove this