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2022;387:205216), tirzepatide achieved mean weight loss of up to approximately 22.5% at the highest dose (15 mg) at 72 weeks in adults with obesity without diabetes results considered exceptional

Simpson JL, Elias S et al

If you have type 2 diabetes and want tirzepatide, the FDA-approved option (Mounjaro) is specifically indicated for your condition and should be discussed with your endocrinologist

But that did not translate to clinical benefits, Jeffrey Cummings, a leader of the trials and a neurologist at the University of Nevada, Las Vegas said at the meeting

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These critical modifications confer a slightly higher affinity to the GLP-1 receptor for both peptides, enabling lower concentrations to achieve equivalent receptor occupancy compared to native GLP-1 [13]