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C max was analysed using the same approach as for the primary endpoint, whereas t max , t , CL/F and V z /F were summarised by hepatic function group using descriptive statistics

Some protocols alternate between daily and reduced frequency

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This D-retro-inverso configuration preserves the three-dimensional side-chain topology of the original FOXO4 sequence maintaining functional mimicry of the FOXO4 forkhead domains interaction surface with p53 while conferring exceptional proteolytic stability compared to the native L-amino acid sequence

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