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Indeed, both CAR T cells and tumor-infiltrating lymphocytes subjected to a signaling rest via BRAF/MEK 26 and tyrosine kinase inhibitors 27 , respectively, underwent reprogramming associated with improved in vivo expansion

Indeed GLP-1R agonists proved to be efficient for the treatment of type 2 diabetes mellitus 37 and studies indicate they could be used in other indications 26,43,44 such as obesity 45,46 , adverse cardiovascular events 25 , cognitive disorders 44 and non-alcoholic steatohepatitis (NASH) 47

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