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In long-term rodent studies, very high doses of tirzepatide caused thyroid tumors, including a rare type called medullary thyroid carcinoma (MTC)

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Live imaging over 5 months showed that epithelioids replicate in vivo cell dynamics

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Conversely, correlation analysis showed that the metabolic correlation co-effects were higher in the serum of both LPS- and papain-induced pneumonia groups than in the control group, indicating common systemic metabolic alterations in both models (Figure 1C)