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In contrast, chronic overnutritionparticularly with hyperglycemia and lipid excessincreases mitochondrial electron pressure and ROS generation, rapidly overwhelming glutathione buffering capacity and accelerating cardiometabolic dysfunction

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Scientists have developed other innovative approaches like intranasal NAD+ sprays and nanoparticle-based co-delivery systems

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While primarily beneficial, dysregulation of GST activity or specific isoforms can contribute to disease pathogenesis