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2.2 Eligibility criteria In selecting studies for this review, we prioritized research that provided meaningful information on the efficacy, safety, and impact of tirzepatide on glycemic and non-glycemic outcomes, such as weight loss and cardiovascular health

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In major studies, adults with obesity (without diabetes) who took the daily oral formulation achieved an average weight loss of approximately 15% to 17% of their body weight over 68 weeks

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Its mutations frequently cause clinical manifestation because of decreased enzyme activity and stability [3]

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