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In September 2025, the agency issued over 50 warning letters to companies selling GLP-1 products (including retatrutide) with marketing that implied human use

Patients taking semaglutides 19 achieved total body weight loss of 5.9% at 3 months and 10.9% at 6 months, which may associated with other lifestyle interventions like diet

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2): The revenue projections for products containing semaglutide and tirzepatide showcase the magnitude of expected revenue in the first five years from launch as compared to other blockbuster drugs

The study authors caution that Reddit users are not representative of the general population

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