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As it turns out, our tongues are programmed with only one receptor that picks up on sweetness, but over 20 receptors that signal bitterness

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In fact, taking it with a large meal can significantly reduce its effectiveness by exposing it to more digestive enzymes

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Patient-centered factors include comorbidities (established ASCVD or indicators of high-risk established kidney disease, or heart failure), the presence of a compelling need to minimize hypoglycemia, the need to promote weight loss or minimize weight gain, and cost [15, 17]