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This enzyme increases levels of a chemical called cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the penis and allows blood to fill the spongy erectile tissues to cause an erection

This is why the STEP trial protocol includes two intermediate doses (1.7 mg) before reaching 2.4 mg, and why many people find their sweet spot below maximum

The researchers who get the best long-term results are almost always the ones who can tolerate weeks of minimal scale movement without abandoning the protocol

Rhonda Patrick discusses the importance of sulfur in glutathione production on the Huberman Lab Podcast

Reduced-dose maintenance is better supported than complete withdrawal, but the exact interval remains uncertain

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