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Critically, low doses (approximately 5x baseline levels) were effective while high doses were not, suggesting a therapeutic window

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Aulinger BA, Bedorf A, Kutscherauer G, et al

201 However, the meta-analysis included only 3 of the 6 RCTs examined by the Work Group and incorporated results from studies outlined in 3 abstracts, but that were never published in peer-reviewed journals

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Common side effects include shakiness, headache, and increased heart rate, which often diminish with continued use